| Teri Hatcher | ... | Susan Mayer / ... (110 episodes, 2004-2009) |
| Felicity Huffman | ... | Lynette Scavo (110 episodes, 2004-2009) |
| Marcia Cross | ... | Bree Hodge / ... (110 episodes, 2004-2009) |
| Eva Longoria Parker | ... | Gabrielle Solis / ... (110 episodes, 2004-2009) |
| Ricardo Chavira | ... | Carlos Solis (110 episodes, 2004-2009) |
| Nicollette Sheridan | ... | Edie Britt (110 episodes, 2004-2009) |
| Brenda Strong | ... | Mary Alice Young (108 episodes, 2004-2009) |
| Doug Savant | ... | Tom Scavo (104 episodes, 2004-2009) |
| James Denton | ... | Mike Delfino (99 episodes, 2004-2009) |
| Andrea Bowen | ... | Julie Mayer (85 episodes, 2004-2008) |
| Brent Kinsman | ... | Preston Scavo / ... (85 episodes, 2004-2008) |
| Shane Kinsman | ... | Porter Scavo / ... (85 episodes, 2004-2008) |
 | Shawn Pyfrom | ... | Andrew Van De Kamp / ... (83 episodes, 2004-2009) |
| Zane Huett | ... | Parker Scavo (81 episodes, 2004-2008) |
| Joy Lauren | ... | Danielle Van De Kamp (71 episodes, 2004-2008) |
| Kyle MacLachlan | ... | Orson Hodge (66 episodes, 2006-2009) |
| Mark Moses | ... | Paul Young (42 episodes, 2004-2007) |
| Cody Kasch | ... | Zach Young (42 episodes, 2004-2007) |
| Kathryn Joosten | ... | Karen McCluskey / ... (42 episodes, 2004-2009) |
| Dana Delany | ... | Katherine Mayfair (39 episodes, 2007-2009) |
| Richard Burgi | ... | Karl Mayer (31 episodes, 2004-2008) |
| Rachel G. Fox | ... | Kayla Huntington / ... (31 episodes, 2006-2008) |
| Steven Culp | ... | Rex Van De Kamp (28 episodes, 2004-2009) |
| Pat Crawford Brown | ... | Ida Greenberg (27 episodes, 2004-2007) |
| Mehcad Brooks | ... | Matthew Applewhite (23 episodes, 2005-2006) |
| Jesse Metcalfe | ... | John Rowland (22 episodes, 2004-2007) |
| Alfre Woodard | ... | Betty Applewhite (20 episodes, 2005-2006) |
| Dougray Scott | ... | Ian Hainsworth (18 episodes, 2006-2007) |
| Harriet Sansom Harris | ... | Felicia Tilman (18 episodes, 2005-2006) |
| Josh Henderson | ... | Austin McCann (17 episodes, 2006-2007) |
| Lyndsy Fonseca | ... | Dylan Mayfair (17 episodes, 2007-2008) |
| Roger Bart | ... | George Williams (15 episodes, 2005-2006) |
| John Slattery | ... | Victor Lang (14 episodes, 2007) |
| Kevin Rahm | ... | Lee McDermott (13 episodes, 2007-2009) |
| Nashawn Kearse | ... | Caleb Applewhite (13 episodes, 2005-2006) |
| Neal McDonough | ... | Dave Williams (12 episodes, 2008-2009) |
| Charles Carver | ... | Porter Scavo (12 episodes, 2008-2009) |
| Max Carver | ... | Preston Scavo (12 episodes, 2008-2009) |
| Tuc Watkins | ... | Bob Hunter (12 episodes, 2007-2009) |
| Joshua Logan Moore | ... | Parker Scavo / ... (12 episodes, 2008-2009) |
| Kendall Applegate | ... | Penny Scavo (12 episodes, 2008-2009) |
| Nathan Fillion | ... | Dr. Adam Mayfair (11 episodes, 2007-2008) |
| Ryan Carnes | ... | Justin (11 episodes, 2004-2006) |
| Bob Gunton | ... | Noah Taylor (10 episodes, 2004-2006) |
| Gale Harold | ... | Jackson Braddock (10 episodes, 2008-2009) |
| Christine Estabrook | ... | Martha Huber (10 episodes, 2004-2009) |
| Currie Graham | ... | Ed Ferrara (9 episodes, 2005-2007) |
| Gwendoline Yeo | ... | Xiao-Mei (9 episodes, 2006) |
| Kiersten Warren | ... | Nora Huntington (8 episodes, 2006) |
| Polly Bergen | ... | Stella Wingfield (8 episodes, 2007-2009) |
| Valerie Mahaffey | ... | Alma Hodge (8 episodes, 2006-2007) |
| Lucille Soong | ... | Yao Lin (8 episodes, 2004-2009) |
| Daniella Baltodano | ... | Celia Solis (8 episodes, 2008-2009) |
| Sam Lloyd | ... | Dr. Albert Goldfine (7 episodes, 2004-2005) |
| Ernie Hudson | ... | Detective Ridley (7 episodes, 2006-2007) |
| Jay Harrington | ... | Dr. Ron McCreadie (7 episodes, 2006) |
| Jeff Doucette | ... | Father Crowley (7 episodes, 2004-2008) |
| Dixie Carter | ... | Gloria Hodge (7 episodes, 2006-2007) |
| Charlie Babcock | ... | Stu (7 episodes, 2005-2008) |
| Madison De La Garza | ... | Juanita Solis (7 episodes, 2008-2009) |
| Lupe Ontiveros | ... | Juanita Solis (6 episodes, 2004-2005) |
| Terry Bozeman | ... | Dr. Craig (6 episodes, 2005-2007) |
| Jason Gedrick | ... | Rick Coletti (6 episodes, 2007-2008) |
| Lesley Ann Warren | ... | Sophie Bremmer (6 episodes, 2005) |
| Gary Cole | ... | Wayne Davis (6 episodes, 2008) |
| Richard Roundtree | ... | Mr. Shaw (6 episodes, 2004-2005) |
| Page Kennedy | ... | Caleb Applewhite (6 episodes, 2005) |
| Jake Cherry | ... | Travers McLain (5 episodes, 2007) |
| Nick Chinlund | ... | Detective Sullivan (5 episodes, 2005-2006) |
| Joely Fisher | ... | Nina Fletcher (5 episodes, 2005) |
| Lee Tergesen | ... | Peter McMillan (5 episodes, 2006) |
| Alec Mapa | ... | Vern (5 episodes, 2005-2007) |
| Shirley Knight | ... | Phyllis Van De Kamp (5 episodes, 2005-2007) |
| Kurt Fuller | ... | Detective Barton (5 episodes, 2005-2006) |
| Betty Murphy | ... | Alberta Fromme (5 episodes, 2004-2006) |
| Alejandro Patino | ... | Ralph (5 episodes, 2005-2006) |
| Dale Waddington Horowitz | ... | Night Nurse / ... (5 episodes, 2007-2008) |
| Lulu | ... | Wisteria Lane Neighborhood Collie (5 episodes, 2006-2007) |
| Lily Tomlin | ... | Roberta (4 episodes, 2008-2009) |
| Laurie Metcalf | ... | Carolyn Bigsby (4 episodes, 2006) |
| Matt Roth | ... | Art Shepherd (4 episodes, 2006) |
| Dakin Matthews | ... | Reverend Sikes (4 episodes, 2005-2008) |
| Gail O'Grady | ... | Anne Schilling (4 episodes, 2008) |
| John Kapelos | ... | Eugene Beale (4 episodes, 2006) |
| Justine Bateman | ... | Ellie Leonard (4 episodes, 2008) |
| Bruce Jarchow | ... | Samuel Bormanis (4 episodes, 2006) |
| Christine Clayburg | ... | Newscaster / ... (4 episodes, 2006-2007) |
| Carol Mansell | ... | Pat Ziegler (4 episodes, 2005-2006) |
| Scott Atkinson | ... | Officer / ... (4 episodes, 2005-2008) |
| Mason Vale Cotton | ... | Maynard 'MJ' Delfino (4 episodes, 2008) |
| Dagney Kerr | ... | Nurse Ruth Ann Heisel (4 episodes, 2005-2006) |
| Richard Jenik | ... | Policeman / ... (4 episodes, 2005-2008) |
| Wayne Lopez | ... | Clyde / ... (4 episodes, 2006-2007) |
| Tanner Maguire | ... | Young Zach (4 episodes, 2005-2006) |
| Todd Grinnell | ... | Dr. Alex Cominis (4 episodes, 2008-2009) |
| Sharon Lawrence | ... | Maisy Gibbons (3 episodes, 2004-2005) |
| Marla Sokoloff | ... | Claire (3 episodes, 2004-2005) |
| Melinda McGraw | ... | Annabel Foster (3 episodes, 2005) |
| Kathryn Harrold | ... | Helen Rowland (3 episodes, 2004-2006) |
| Stacey Travis | ... | Jordana Geist (3 episodes, 2004-2007) |
| Conor O'Farrell | ... | Detective Copeland (3 episodes, 2005) |
| Harry S. Murphy | ... | Headmaster Lentz (3 episodes, 2004-2005) |
| Ellen Geer | ... | Lillian Sims (3 episodes, 2007-2008) |
| Paul Dooley | ... | Addison Prudy (3 episodes, 2005) |
| Kathleen York | ... | Monique Pollier (3 episodes, 2006-2007) |
| Adrian Pasdar | ... | David Bradley (3 episodes, 2005) |
| Bob Newhart | ... | Morty Flickman (3 episodes, 2005) |
| Mike Farrell | ... | Milton Lang (3 episodes, 2007-2008) |
| David Fabrizio | ... | Detective Collins (3 episodes, 2006-2008) |
| Melinda Page Hamilton | ... | Sister Mary Bernard (3 episodes, 2005-2006) |
| Eddie McClintock | ... | Frank Helm (3 episodes, 2006) |
| James Luca McBride | ... | Al Kaminsky (3 episodes, 2007) |
| Michael Durrell | ... | Mr. Katzburg (3 episodes, 2006) |
| Nichole Hiltz | ... | Libby Collins (3 episodes, 2006) |
| James Shanklin | ... | Detective Fallon / ... (3 episodes, 2005-2006) |
| Kylie Sparks | ... | Kim (3 episodes, 2007) |
| Frances Conroy | ... | Virginia Hildebrand / ... (3 episodes, 2008) |
| Jill Brennan | ... | Tish Atherton (3 episodes, 2005-2006) |
| Maria Cominis | ... | Mona Clark / ... (3 episodes, 2005-2006) |
| Soledad St. Hilaire | ... | Helena (3 episodes, 2007) |
| Cheyenne Wilbur | ... | Bob Fisk / ... (3 episodes, 2004-2005) |
| Dougald Park | ... | The Doctor / ... (3 episodes, 2006) |
| Mitch Silpa | ... | Jerry (3 episodes, 2006-2007) |
| Mark Brady | ... | Jail Cell Officer / ... (3 episodes, 2004-2008) |
| Steve Tyler | ... | Minister (3 episodes, 2007) |
| Jolie Jenkins | ... | Deirdre (3 episodes, 2005) |
| Stephen Spinella | ... | Dr. Heller / ... (3 episodes, 2008) |
| Emily Christine | ... | Ashley Bukowski (3 episodes, 2004-2005) |
| Paul Keeley | ... | Dr. McLean / ... (3 episodes, 2006-2007) |
| Wendy Worthington | ... | Nurse Parker (3 episodes, 2006-2007) |
| Hailee Denham | ... | Young Dylan Mayfair (3 episodes, 2007-2008) |
| Jordan Timsit | ... | Lori Jean's Son / ... (3 episodes, 2004-2005) |
| Cecily Gambrell | ... | Jane Hainsworth (3 episodes, 2006-2007) |
| Brett Cullen | ... | Detective Burnett (2 episodes, 2004-2005) |
| Gregg Daniel | ... | Dr. Sicher (2 episodes, 2004) |
| Mary Pat Gleason | ... | Ms. Butters / ... (2 episodes, 2004-2008) |
| Shawn Doyle | ... | Mr. Hartley (2 episodes, 2004-2005) |
| Mark L. Taylor | ... | Mr. Steinberg (2 episodes, 2005) |
| John Newton | ... | Jonathan Lithgow - The Cable Guy (2 episodes, 2004-2005) |
| Michael Ironside | ... | Curt Monroe (2 episodes, 2005-2006) |
| Anthony Azizi | ... | Mr. Falati (2 episodes, 2006) |
| Heather Stephens | ... | Kendra Taylor (2 episodes, 2004-2005) |
| Miriam Flynn | ... | Dr. Berman (2 episodes, 2007) |
| Peter Onorati | | (2 episodes, 2008) |
| William Atherton | ... | Dr. Barr (2 episodes, 2006) |
| Jennifer Dundas | ... | Rebecca Shepard (2 episodes, 2006) |
| Melora Walters | ... | Sylvia Greene (2 episodes, 2007) |
| Michelle Pierce | ... | Tammy Rowland / ... (2 episodes, 2006-2007) |
| Edward Edwards | ... | Jim Peterson (2 episodes, 2004-2005) |
| Shannon O'Hurley | ... | Mrs. Truesdale (2 episodes, 2004-2005) |
| Nigel Gibbs | ... | FBI Agent (2 episodes, 2004) |
| Brian Kerwin | ... | Harvey Bigsby (2 episodes, 2006) |
| Nike Doukas | ... | Natalie Klein (2 episodes, 2004-2005) |
| Mark Deklin | ... | Bill Pearce (2 episodes, 2006-2007) |
| Julie White | ... | Amanda (2 episodes, 2006) |
| Billy Mayo | ... | Detective Lyons (2 episodes, 2007-2008) |
| Peter Birkenhead | ... | Dr. Dolan / ... (2 episodes, 2008) |
| Jodi Carlisle | ... | Michelle Downing / ... (2 episodes, 2008) |
| Carlease Burke | ... | Nurse #2 / ... (2 episodes, 2004-2005) |
| Andy Umberger | ... | Detective Romslow / ... (2 episodes, 2005-2008) |
| Peter Jason | ... | Jeff / ... (2 episodes, 2006-2007) |
| Rick Otto | ... | Det. Paul Bullock (2 episodes, 2008) |
| Roz Witt | ... | Nurse #1 / ... (2 episodes, 2004-2005) |
| Michael Bofshever | ... | Mr. Stevens (2 episodes, 2006) |
| John Bobek | ... | Tucker (2 episodes, 2007) |
| Elizabeth Storm | ... | Janie Peterson (2 episodes, 2004-2005) |
| Mary Margaret Lewis | ... | Renee / ... (2 episodes, 2006-2007) |
| Rick Fitts | ... | Jerry the Coroner / ... (2 episodes, 2006) |
| John Lacy | ... | Detective Beckerman (2 episodes, 2004-2005) |
| Ridge Canipe | ... | Danny Farrell (2 episodes, 2005-2007) |
| Juliette Goglia | ... | Amy Pearce (2 episodes, 2006) |
| Jeffrey Stubblefield | ... | Jerome (2 episodes, 2007) |
| Joyce Van Patten | ... | Carol Prudy (2 episodes, 2005) |
| John Mariano | ... | Oliver Weston (2 episodes, 2006) |
| David Pevsner | ... | Waiter (2 episodes, 2005-2006) |
| Scott Allan Campbell | ... | Detective Sloan (2 episodes, 2005) |
| Lynette DuPree | ... | Nurse / ... (2 episodes, 2007) |
| Billy Unger | ... | Chad / ... (2 episodes, 2007) |
| Julie Pop | ... | Nurse (2 episodes, 2007) |
| Albert Garcia | ... | Luis (2 episodes, 2005-2006) |
| Tim Monsion | ... | Dr. Cunningham (2 episodes, 2006) |
| Darien Pinkerton | ... | Penny / ... (2 episodes, 2007) |
| Felice Heather Monteith | ... | Mike's Nurse (2 episodes, 2006) |
| Chloe Moretz | ... | Sherri Maltby (2 episodes, 2006-2007) |
| John Callahan | ... | Stan (2 episodes, 2006) |
| Jennifer Lyons | ... | Cecile the Stripper (2 episodes, 2006) |
| Stephen O'Mahoney | ... | Paramedic / ... (2 episodes, 2007) |
| Leslie Karpman | ... | Debbie / ... (2 episodes, 2008) |
| Lenny Schmidt | ... | Man / ... (2 episodes, 2006) |
| Chris Damiano | ... | Cop / ... (2 episodes, 2006-2007) |
| John Harnagel | ... | Gilbert McCluskey (2 episodes, 2007) |
| Joy Bisco | ... | Melanie Foster (2 episodes, 2005-2006) |
| J. Omar Castro | ... | Guard (2 episodes, 2007) |
| Coley Sohn | ... | Nurse (2 episodes, 2007) |
| Cristos | ... | Inmate / ... (2 episodes, 2006-2007) |
| Joanna Cassidy | ... | Melina Cominis (2 episodes, 2009) |
| Paul Rae | ... | Hector 'The Ice Cream Man' (2 episodes, 2005) |
| Boo Arnold | ... | Cop / ... (2 episodes, 2006) |
| Alicia Brandt | ... | Judy (2 episodes, 2005-2006) |
| Mark Arnold | ... | Jack (2 episodes, 2005) |
| Trisha Simmons | ... | Principal Star / ... (2 episodes, 2004-2005) |
| Randy Spire | ... | Alfred the Orderly / ... (2 episodes, 2006) |
| Garrett Warren | ... | Gangbanger #1 / ... (2 episodes, 2005-2006) |
| Hunter Allan | ... | Young Andrew (2 episodes, 2006) |
| Kerstin Pinkerton | ... | Penny / ... (2 episodes, 2007) |
| Joshua Bevier | ... | Pharmacist (2 episodes, 2004-2005) |
| Dawn Ashley Cook | ... | Serena / ... (2 episodes, 2005-2006) |
| Shannon Ryan | ... | Bree's Laughing Dinner Guest / ... (2 episodes, 2006-2007) |
| Marina Anderson-Carradine | ... | Wisteria Lane Neighbor with Collie (2 episodes, 2006) |
| Derrick Brady | ... | Office Employee / ... (2 episodes, 2006) |
| Faith Dever | ... | Baby Lilly (2 episodes, 2006) |
| Hope Dever | ... | Baby Lilly (2 episodes, 2006) |
| Gina Fricchione | ... | Maxine Bennett's Friend / ... (2 episodes, 2006) |
| Erin O'Shaughnessy | ... | Clair (2 episodes, 2008-2009) |
| Bob Ross | ... | Doctor / ... (2 episodes, 2008-2009) |
| Arlo Hemphill | ... | Fireman / ... (2 episodes, 2008) |
